Biocatalysis has become an established technology for the industrial manufacture of fine chemicals and active pharma. The application of enzymes as catalysts for chemical synthesis, has become a valuable tool for the synthetic chemist. Enzymatic transformations carried out by partially purified enzymes or whole-cell catalysts are used for the production of a wide variety of chemicals, from bulk to fine chemicals.
In recent years, chemical companies have embraced biocatalysis for the manufacture of desired stereoisomers, and new or improved methods for the synthesis of enantiomerically pure alpha- and beta-amino acids, amines, amides, peptides, nitriles, alcohols etc. have emerged.
Furthermore, the selectivity and mild operational conditions of biocatalysts are increasingly applied in industry to modify complex target molecules. These recent innovations in the manufacture of industrial fine chemicals using biocatalysis are discussed from an industrial perspective.
Several procedures have been reported for the development of biocatalytic processes comprising integrating biocatalysts into a variety of industrially interesting processes ranging from the manufacture of smaller, chiral speciality chemicals to the synthesis of more complex pharmaceutical intermediates. The use of rational protein design, multistep processes and de novo design of enzyme catalysts for the stereocontrolled preparation of important target structures further contributed to its success.
Procedures have been established for biocatalytic single-step reactions. Multi-step reactions and multi-component reactions enable an approach where biocatalytic reactions work together in one compartment and reactions hindering each other within different compartments or steps. The understanding of the catalytic functions of known and new enzymes is key for the development of new sustainable chemical transformations.

Immobilization technology

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Today state of the art carriers provide excellent immobilized enzyme products. ChiralVision is the leading company in the development and manufacturing of an innovative range of carriers for various industries, including life sciences / pharma, chemical, intermediate, cosmetics and personal care, energy and environment. Many of our products are used as catalysts in various industrial processes.

ChiralVision offers customers across a broad array of markets tomorrows industrial biosolutions, improving our customers' business. Immobilized enzymes help towards a better environment and reduced production costs, improve the safety and stability. With our guaranteed promise of consistency and long-term supply, we can streamline your product development process, allowing you to commercialize your product faster, while maintaining safety and compliance.

To learn more about our products just click on our product catalogs or call one of our representatives for more details.

ChiralVisions Immobead(TM) caught on a 50 micrometer filter.

SpinChem reactor

SpinChem® is an innovative and unique concept for mass transfer enhancement in reactions involving solid phase reagents, encompassing several different ways of using the stirring element itself to establish a forced flow through a heterogeneous reactant or catalyst bed, which is located inside the stirrer body.

SpinChem reactor

Improved Mass Transfer: The conventional way of carrying out batch processing with solid-phase reagents is to suspend the particulate material directly in the stirred reaction mixture. This causes the reagent particles to be carried along by a largely laminar fluid flow and often results in production of fines due to mechanical wear.

Inter-phase mass transport in a stirred suspension takes place mainly by diffusion, which is notoriously slow in liquids. Rather extreme stirring is therefore needed to create the turbulent flow necessary to establish convective mass transfer. The smaller the surface area and the lower the number of particles used, the slower the reaction will be, and the solid reagent is therefore often dosed in unnecessary high amounts.

SpinChem® presents the optimal solution to this problem by providing an efficient way of continuously percolating the reagent/catalyst/scavenger bed with fresh reaction solution. This ensures optimum mass transfer, minimizes production of fines caused by grinding effects, and saves time and reagents. The SpinChem® system is furthermore scalable from laboratory through pilot and production scales.